The liver connects the intestinal portal vasculature with the general circulation, using a
diverse array of immune cells to protect from pathogens that translocate from the gut. In liver …

Receiving both portal vein blood and arterial blood, the liver is an important and critical
component in the defense against blood-borne infection. To accomplish this role, the liver …

The responses of CD8+ T cells to hepatotropic viruses such as hepatitis B range from
dysfunction to differentiation into effector cells, but the mechanisms that underlie these …

The intestine is a complex organ that promotes digestion, extracts nutrients, participates in
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …

Kupffer cells (KCs) are localized in liver sinusoids but extend pseudopods to parenchymal
cells to maintain their identity and serve as the body's central bacterial filter. Liver cirrhosis …

Systemic infection induces conserved physiological responses that include both resistance
and 'tolerance of infection'mechanisms. Temporary anorexia associated with an infection is …

The human liver is an essential multifunctional organ. The incidence of liver diseases is
rising and there are limited treatment options. However, the cellular composition of the liver …

A prerequisite for establishment of mutualism between the host and the microbial community
that inhabits the large intestine is the stringent mucosal compartmentalization of …

The mammalian immune system implements a remarkably effective set of mechanisms for
fighting pathogens. Its main components are haematopoietic immune cells, including …

Immune cells rely on transient physical interactions with other immune and non-immune
populations to regulate their function. To study these 'kiss-and-run'interactions directly in …