BackgroundOver the past several decades, more research focuses have been made on the
inflammation/immune hypothesis of schizophrenia. Building upon synaptic plasticity …

The last decades of research in schizophrenia witnessed a shift of etiological speculation
from neurotransmitters to inflammation. However, identifying definite inflammatory effectors …

Deficits in brain morphology are one of the most widely replicated neuropathological
features in schizophrenia-spectrum disorder (SSD), although their biological underpinnings …

Objective Immune system dysfunction is hypothesised to contribute to structural brain
changes through aberrant synaptic pruning in schizophrenia. However, evidence is mixed …

Background Inflammation has been implicated in the pathology of schizophrenia and may
cause neuronal cell death and dendrite loss. Neuroimaging studies have highlighted …

Importance Previous in vitro and postmortem research suggests that inflammation may lead
to structural brain changes via activation of microglia and/or astrocytic dysfunction in a range …

Genetic, epidemiological and post-mortem studies implicate inflammation in the
pathogenesis of schizophrenia. While inflammation can regulate neurogenesis, and is …

Neuroinflammatory events prior to the diagnosis of schizophrenia may play a role in
transition to illness. To date only one in-vivo study has investigated this association between …

Background Complex immune-brain interactions that affect neural development, survival
and function might have causal and therapeutic implications for psychiatric illnesses …

Schizophrenia is a severe neuropsychiatric disorder associated with a wide array of
transcriptomic and neurobiochemical changes. Genome-wide transcriptomic profiling …