Viral-human chimeric transcript predisposes risk to liver cancer development and progression
The mutagenic effect of hepatitis B (HBV) integration in predisposing risk to hepatocellular
carcinoma (HCC) remains elusive. In this study, we performed transcriptome sequencing of …
carcinoma (HCC) remains elusive. In this study, we performed transcriptome sequencing of …
[HTML][HTML] The function of targeted host genes determines the oncogenicity of HBV integration in hepatocellular carcinoma
X Li, J Zhang, Z Yang, J Kang, S Jiang, T Zhang… - Journal of …, 2014 - Elsevier
Background & Aims Although hepatitis B virus (HBV) integration into the human genome has
been considered as one of the major causative factors to hepatocarcinogenesis, the …
been considered as one of the major causative factors to hepatocarcinogenesis, the …
The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients
Hepatitis B virus (HBV) infection is a leading risk factor for hepatocellular carcinoma (HCC).
HBV integration into the host genome has been reported, but its scale, impact and …
HBV integration into the host genome has been reported, but its scale, impact and …
Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma
Objective Infection by HBV is the main risk factor for hepatocellular carcinoma (HCC)
worldwide. HBV directly drives carcinogenesis through integrations in the human genome …
worldwide. HBV directly drives carcinogenesis through integrations in the human genome …
Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing–based approach
Integration of the viral DNA into host chromosomes was found in most of the hepatitis B virus
(HBV)–related hepatocellular carcinomas (HCCs). Here we devised a massive anchored …
(HBV)–related hepatocellular carcinomas (HCCs). Here we devised a massive anchored …
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
To survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted
massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular …
massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular …
Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma
Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic
instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration …
instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration …
[HTML][HTML] Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers
M Furuta, H Tanaka, Y Shiraishi, T Unida, M Imamura… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Integration of Hepatitis B virus (HBV) into the human genome can cause genetic instability,
leading to selective advantages for HBV-induced liver cancer. Despite the large number of …
leading to selective advantages for HBV-induced liver cancer. Despite the large number of …
Deep sequencing of the hepatitis B virus in hepatocellular carcinoma patients reveals enriched integration events, structural alterations and sequence variations
ST Toh, Y Jin, L Liu, J Wang, F Babrzadeh… - …, 2013 - academic.oup.com
Chronic hepatitis B virus (HBV) infection is epidemiologically associated with hepatocellular
carcinoma (HCC), but its role in HCC remains poorly understood due to technological …
carcinoma (HCC), but its role in HCC remains poorly understood due to technological …
[HTML][HTML] Role of hepatitis B virus DNA integration in human hepatocarcinogenesis
Liver cancer ranks sixth in cancer incidence, and is the third leading cause of cancer-related
deaths worldwide. Hepatocellular carcinoma (HCC) is the most common type of liver cancer …
deaths worldwide. Hepatocellular carcinoma (HCC) is the most common type of liver cancer …