The physical microenvironment of cancer is characterized by elevated stiffness and tissue
pressure, the main component of which is the interstitial fluid pressure (IFP). Elevated IFP is …

Solid tumors have a raised interstitial fluid pressure (IFP) due to high vessel permeability,
low lymphatic drainage, poor perfusion, and high cell density around the blood vessels. To …

Elevated interstitial fluid pressure (IFP) in tumors can cause metastatic dissemination and
treatment resistance, but its study poses a challenge because of a paucity of noninvasive …

Tumor interstitial fluid pressure (TIFP), is a physiological parameter with demonstrated
predictive value for a tumor's aggressiveness, drug delivery, as well as response to …

High tumor interstitial fluid pressure (TIFP) is a characteristic of most solid tumors. TIFP may
hamper adequate uptake of macromolecular therapeutics in tumor tissue. In addition, TIFP …

Tumor interstitial fluid pressure (TIFP) has the potential to predict tumor response to
nonsurgical cancer treatments, including radiation therapy. At present the only quantitative …

Solid tumors are characterized by high interstitial fluid pressure, which drives fluid efflux from
the tumor core. Tumor-associated interstitial flow (IF) at a rate of∼ 3 µm/s has been shown to …

Cancer progression is caused by genetic changes and associated with various alterations in
cell properties, which also affect a tumor's mechanical state. While an increased stiffness …

Introduction: Elevated tumor interstitial fluid pressure (TIFP) is a major barrier to successful
cancer treatment. It is mainly caused by an inadequate tumor perfusion resulting from …

Elevated interstitial fluid pressure (IFP) may constitute a significant physiological barrier to
drug delivery in solid tumors. Strategies for overcoming this barrier have not been …