scGPT: toward building a foundation model for single-cell multi-omics using generative AI

H Cui, C Wang, H Maan, K Pang, F Luo, N Duan… - Nature …, 2024 - nature.com
Generative pretrained models have achieved remarkable success in various domains such
as language and computer vision. Specifically, the combination of large-scale diverse …

Large-scale foundation model on single-cell transcriptomics

M Hao, J Gong, X Zeng, C Liu, Y Guo, X Cheng… - Nature …, 2024 - nature.com
Large pretrained models have become foundation models leading to breakthroughs in
natural language processing and related fields. Developing foundation models for …

Transfer learning enables predictions in network biology

CV Theodoris, L Xiao, A Chopra, MD Chaffin… - Nature, 2023 - nature.com
Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …

Probabilistic harmonization and annotation of single‐cell transcriptomics data with deep generative models

C Xu, R Lopez, E Mehlman, J Regier… - Molecular systems …, 2021 - embopress.org
As the number of single‐cell transcriptomics datasets grows, the natural next step is to
integrate the accumulating data to achieve a common ontology of cell types and states …

[PDF][PDF] SERGIO: a single-cell expression simulator guided by gene regulatory networks

P Dibaeinia, S Sinha - Cell systems, 2020 - cell.com
A common approach to benchmarking of single-cell transcriptomics tools is to generate
synthetic datasets that statistically resemble experimental data. However, most existing …

How will generative AI disrupt data science in drug discovery?

JP Vert - Nature Biotechnology, 2023 - nature.com
In the short few months since the release of ChatGPT 1, 2, the potential for large language
models (LLMs) and generative artificial intelligence (AI) to disrupt fields as diverse as art …

Enhancing scientific discoveries in molecular biology with deep generative models

R Lopez, A Gayoso, N Yosef - Molecular systems biology, 2020 - embopress.org
Generative models provide a well‐established statistical framework for evaluating
uncertainty and deriving conclusions from large data sets especially in the presence of …

[HTML][HTML] VEGA is an interpretable generative model for inferring biological network activity in single-cell transcriptomics

L Seninge, I Anastopoulos, H Ding, J Stuart - Nature communications, 2021 - nature.com
Deep learning architectures such as variational autoencoders have revolutionized the
analysis of transcriptomics data. However, the latent space of these variational …

[HTML][HTML] Learning interpretable cellular and gene signature embeddings from single-cell transcriptomic data

Y Zhao, H Cai, Z Zhang, J Tang, Y Li - Nature communications, 2021 - nature.com
The advent of single-cell RNA sequencing (scRNA-seq) technologies has revolutionized
transcriptomic studies. However, large-scale integrative analysis of scRNA-seq data remains …

Deep generative modeling for single-cell transcriptomics

R Lopez, J Regier, MB Cole, MI Jordan, N Yosef - Nature methods, 2018 - nature.com
Single-cell transcriptome measurements can reveal unexplored biological diversity, but they
suffer from technical noise and bias that must be modeled to account for the resulting …