Aging affects all tissues and organs. Aging of the immune system results in the severe
disruption of its functions, leading to an increased susceptibility to infections, an increase in …

Adults over 65 years of age are more vulnerable to infectious disease and show poor
responses to vaccination relative to those under 50. A complex set of age-related changes in …

The immune system undergoes age-associated changes known as immunosenescence,
resulting in increased susceptibility to infections, cancers and autoimmunity in the aged. The …

The world is witnessing a rapid demographic shift towards an older population, a trend with
major medical, social, economic and political implications. Aging is a multifaceted process …

Immunosenescence is a multi-faceted phenomenon at the root of age-associated immune
dysfunction. It can lead to an array of pathological conditions, including but not limited to a …

The elderly have a decreased response to vaccination and an increased susceptibility to
infectious diseases. The spleen and lymph nodes are important secondary lymphoid organs …

Aging is associated with decreased immune function that leads to increased morbidity and
mortality in the elderly. Immune senescence is accompanied by age-related changes in two …

Understanding why we age and how that process can be delayed or reversed are topics that
have engaged both researchers and the general public [1]. From a scientific perspective …

The effects of aging on the immune system are widespread and extend from hematopoietic
stem cells and lymphoid progenitors in the bone marrow and thymus to mature lymphocytes …

Highlights•Immune function declines with age.•Extrinsic factors contribute towards
immunosenescence.•Aged stromal niche offers a potential target for therapy.The major …