Key mutations in the spike protein of SARS‐CoV‐2 affecting neutralization resistance and viral internalization

Q Wang, SB Ye, ZJ Zhou, AL Song… - Journal of Medical …, 2023 - Wiley Online Library
To control the ongoing COVID‐19 pandemic, a variety of severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) vaccines have been developed. However, the rapid mutations …

The E484K substitution in a SARS-CoV-2 spike protein subunit vaccine resulted in limited cross-reactive neutralizing antibody responses in mice

L Hu, Y Xu, L Wu, J Feng, L Zhang, Y Tang, X Zhao… - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially emerging
variants, poses an increased threat to global public health. The significant reduction in …

Evaluation of humoral immune responses induced by different SARS‐CoV‐2 spike trimers from wild‐type and emerging variants with individual, sequential, and …

C Ding, S Ni, X Zhang, J Xie, Y Sun, J He… - Journal of Medical …, 2022 - Wiley Online Library
The spike trimer of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is an
effective target for inducing neutralizing antibodies by coronavirus disease 2019 (COVID …

Significance of conserved regions in coronavirus spike protein for developing a novel vaccine against SARS-CoV-2 infection

TA Olukitibi, Z Ao, B Warner, R Unat, D Kobasa, X Yao - Vaccines, 2023 - mdpi.com
Over the years, several distinct pathogenic coronaviruses have emerged, including the
pandemic SARS-CoV-2, which is difficult to curtail despite the availability of licensed …

Monoclonal antibodies against S2 subunit of spike protein exhibit broad reactivity toward SARS-CoV-2 variants

SH Ko, WY Chen, SC Su, HT Lin, FY Ke… - Journal of Biomedical …, 2022 - Springer
Background The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
harbor diverse spike (S) protein sequences, which can greatly influence the efficacies of …

Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

Z Liu, LA VanBlargan, LM Bloyet, PW Rothlauf… - Cell host & …, 2021 - cell.com
Neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of COVID-19
vaccines and have received emergency use authorization as therapeutics. However, viral …

[HTML][HTML] The E484K mutation in the SARS-CoV-2 spike protein reduces but does not abolish neutralizing activity of human convalescent and post-vaccination sera.

S Jangra, C Ye, R Rathnasinghe, D Stadlbauer… - MedRxiv, 2021 - ncbi.nlm.nih.gov
One year in the coronavirus disease 2019 (COVID-19) pandemic, the first vaccines are
being rolled out under emergency use authorizations. It is of great concern that newly …

[HTML][HTML] Will mutations in the spike protein of SARS-CoV-2 lead to the failure of COVID-19 vaccines?

Z Jia, W Gong - Journal of Korean medical science, 2021 - synapse.koreamed.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of
coronavirus disease 2019 (COVID-19), which has spread worldwide since it was first …

Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

R Bos, L Rutten, JEM van der Lubbe, MJG Bakkers… - npj Vaccines, 2020 - nature.com
Abstract Development of effective preventative interventions against SARS-CoV-2, the
etiologic agent of COVID-19 is urgently needed. The viral surface spike (S) protein of SARS …

[HTML][HTML] The effect of spike mutations on SARS-CoV-2 neutralization

C Rees-Spear, L Muir, SA Griffith, J Heaney, Y Aldon… - Cell reports, 2021 - cell.com
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show
protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the …