Novel aspects of renal magnesium homeostasis

P Giménez-Mascarell, CE Schirrmacher… - Frontiers in …, 2018 - frontiersin.org
Magnesium (Mg2+) is indispensable for several vital functions, such as neurotransmission,
cardiac conductance, blood glucose, blood pressure regulation, and proper function of more …

Magnesium homeostasis: lessons from human genetics

AR Morrison - Clinical Journal of the American Society of …, 2023 - journals.lww.com
Mg 2+, the fourth most abundant cation in the body, serves as a cofactor for about 600
cellular enzymes. One third of ingested Mg 2+ is absorbed from the gut through a saturable …

Genetics of magnesium disorders

H Li, S Sun, J Chen, G Xu, H Wang, Q Qian - Kidney Diseases, 2017 - karger.com
Background: Magnesium (Mg 2+), the second most abundant cation in the cell, is woven into
a multitude of cellular functions. Dysmagnesemia is associated with multiple diseases and …

Novel molecular pathways in renal Mg2+ transport: a guided tour along the nephron

P San-Cristobal, H Dimke, JGJ Hoenderop… - Current Opinion in …, 2010 - journals.lww.com
Novel molecular pathways in renal Mg2+ transport: a guided t... : Current Opinion in Nephrology
and Hypertension Novel molecular pathways in renal Mg2+ transport: a guided tour along the …

Regulation of magnesium balance: lessons learned from human genetic disease

JHF De Baaij, JGJ Hoenderop… - Clinical kidney …, 2012 - academic.oup.com
Abstract Magnesium (Mg2+) is the fourth most abundant cation in the body. Thus,
magnesium homeostasis needs to be tightly regulated, and this is facilitated by intestinal …

Evolving concepts in epithelial magnesium transport

SL Alan - Current opinion in nephrology and hypertension, 2001 - journals.lww.com
Magnesium is an important, predominantly intracellular cation that is required for a wide
variety of cellular processes. The mammalian kidney plays a key role in whole-body …

[PDF][PDF] Role of the distal convoluted tubule in renal Mg 2+ handling: molecular lessons from inherited hypomagnesemia

S Ferrè, JJG Hoenderop, RJM Bindels - Magnesium Research, 2011 - academia.edu
In healthy individuals, Mg2+ homeostasis is tightly regulated by the concerted action of
intestinal absorption, exchange with bone, and renal excretion. The kidney, more precisely …

Inherited disorders of renal magnesium handling

DEC Cole, GA Quamme - Journal of the American Society of …, 2000 - journals.lww.com
The genetic basis and cellular defects of a number of primary magnesium wasting diseases
have been elucidated over the past decade. This review correlates the clinical …

Mechanisms of paracellular transport of magnesium in intestinal and renal epithelia

P Houillier, L Lievre, M Hureaux… - Annals of the New …, 2023 - Wiley Online Library
Magnesium is the fourth most abundant cation in the body. It plays a critical role in many
biological processes, including the process of energy release. Paracellular transport of …

Recent advances in molecular genetics of hereditary magnesium-losing disorders

M Konrad, S Weber - Journal of the American Society of …, 2003 - journals.lww.com
Recent advances in molecular genetics in hereditary hypomagnesemia substantiated the
role of a variety of genes and their encoded proteins in human magnesium transport …