Resolution of inflammation: An organizing principle in biology and medicine

D Panigrahy, MM Gilligan, CN Serhan… - Pharmacology & …, 2021 - Elsevier
The resolution of inflammation has emerged as a critical endogenous process that protects
host tissues from prolonged or excessive inflammation that can become chronic. Failure of …

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

CN Serhan, N Chiang, J Dalli - Seminars in immunology, 2015 - Elsevier
Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion
injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro …

Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of inflammation

Y Isobe, T Kato, M Arita - Frontiers in immunology, 2012 - frontiersin.org
Acute inflammation and its resolution are essential processes for tissue protection and
homeostasis. Once thought to be a passive process, the resolution of inflammation is now …

Lipid mediators in the resolution of inflammation

CN Serhan, N Chiang, J Dalli… - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Mounting of the acute inflammatory response is crucial for host defense and pivotal to the
development of chronic inflammation, fibrosis, or abscess formation versus the protective …

[HTML][HTML] Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?

CN Serhan - The American journal of pathology, 2010 - Elsevier
Because inflammation is appreciated as a unifying basis of many widely occurring diseases,
the mechanisms involved in its natural resolution are of considerable interest. Using …

Endogenous pro‐resolving and anti‐inflammatory lipid mediators: a new pharmacologic genus

CN Serhan, N Chiang - British journal of pharmacology, 2008 - Wiley Online Library
Complete resolution of an acute inflammatory response and its return to homeostasis are
essential for healthy tissues. Here, we overview ongoing efforts to characterize cellular and …

Novel anti-inflammatory-pro-resolving mediators and their receptors

CN Serhan, S Krishnamoorthy… - Current topics in …, 2011 - ingentaconnect.com
Resolution of inflammation, an actively coordinated program, is essential to maintain host
health. It involves effective removal of inflammatory stimuli and the spatio-temporal control of …

[HTML][HTML] Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

CN Serhan - The FASEB Journal, 2017 - ncbi.nlm.nih.gov
Practitioners of ancient societies from the time of Hippocrates and earlier recognized and
treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or …

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

CN Serhan, N Chiang, TE Van Dyke - Nature Reviews Immunology, 2008 - nature.com
Active resolution of acute inflammation is a previously unrecognized interface between
innate and adaptive immunity. Once thought to be a passive process, the resolution of …

Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways

CN Serhan - Annu. Rev. Immunol., 2007 - annualreviews.org
Resolution of inflammation and the return of tissues to homeostasis are essential. Efforts to
identify molecular events governing termination of self-limited inflammation uncovered …