The changing expression levels of ocular proteins in response to systemic disease has been
well established in literature. In this study, we examined the ocular proteome to identify …

Background: Early detection of breast cancer reduces breast cancer-related mortality. Breast
cancer biomarkers offer a promising means of detecting this disease at the earliest and most …

Noninvasive biomarkers are urgently needed for early detection of breast cancer since the
risk of recurrence, morbidity and mortality are closely related to disease stage at the time of …

A thin layer of tears covers the ocular surface. The tears are a complex fluid comprised of
secretions from a number of sources including the lacrimal gland, goblet cells, cornea, and …

Considering absence of invasiveness and side effects, tears emerge as a particularly
attractive fluid for biomarker discovery and therefore for daily clinical use. However, to date …

Proteins in tears have an important role in eye health and have been shown as a promising
source of disease biomarkers. The goal of this study was to develop a robust, sensitive, and …

Purpose Human tears contain abundant, diverse sets of proteins that may serve as
biomarkers of ocular surface health. There is a need for reproducible methods that consider …

Purpose: The purpose of this study was to examine the protein profile differences between
capillary and Schirmer strip tear fluid samples. Methods: Both capillary and Schirmer strip …

Background Prevalence of many eye and ocular surface diseases increases with age. While
the clinical characteristics and pathophysiologic mechanisms of these conditions are often …

Background Diseases of the anterior segment of the eye may present different mechanisms,
intensity of symptoms, and impact on the patients' quality of life and vision. The tear film is in …