SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells

N Huot, C Planchais, P Rosenbaum, V Contreras… - Nature …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA generally becomes
undetectable in upper airways after a few days or weeks postinfection. Here we used a …

Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

CE Nelson, S Namasivayam, TW Foreman… - Science …, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily replicates in
mucosal sites, and more information is needed about immune responses in infected tissues …

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

RA Grant, L Morales-Nebreda, NS Markov… - Nature, 2021 - nature.com
Some patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
develop severe pneumonia and acute respiratory distress syndrome (ARDS). Distinct …

Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques

C Shan, YF Yao, XL Yang, YW Zhou, G Gao, Y Peng… - Cell research, 2020 - nature.com
The 2019 novel coronavirus (SARS-CoV-2) outbreak is a major challenge for public health.
SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe …

NK cells: A double edge sword against SARS-CoV-2

E Masselli, M Vaccarezza, C Carubbi, G Pozzi… - Advances in biological …, 2020 - Elsevier
Natural killer (NK) cells are pivotal effectors of the innate immunity protecting an individual
from microbes. They are the first line of defense against invading viruses, given their …

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

A Chandrashekar, J Liu, AJ Martinot, K McMahan… - Science, 2020 - science.org
An understanding of protective immunity to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is critical for vaccine and public health strategies aimed at ending the global …

Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

W Deng, L Bao, J Liu, C Xiao, J Liu, J Xue, Q Lv, F Qi… - Science, 2020 - science.org
Coronavirus disease 2019 (COVID-19), which is caused by infection with the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. It is …

Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19

P Laurent, C Yang, AF Rendeiro… - Science …, 2022 - science.org
Lung-infiltrating macrophages create a marked inflammatory milieu in a subset of patients
with COVID-19 by producing a cytokine storm, which correlates with increased lethality …

Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets

DK Singh, B Singh, SR Ganatra, M Gazi, J Cole… - Nature …, 2021 - nature.com
Non-human primate models will expedite therapeutics and vaccines for coronavirus disease
2019 (COVID-19) to clinical trials. Here, we compare acute severe acute respiratory …

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

C Junqueira, Â Crespo, S Ranjbar, LB De Lacerda… - Nature, 2022 - nature.com
SARS-CoV-2 can cause acute respiratory distress and death in some patients. Although
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …