Sarcopenia, the degenerative loss of skeletal muscle mass, quality and strength, lacks early
diagnostic tools and new therapeutic strategies to prevent the frailty-to-disability transition …

Apelin constitutes a novel endogenous peptide system suggested to be involved in a broad
range of physiological functions, including cardiovascular function, heart development …

Aging drives the occurrence of numerous diseases, including cardiovascular disease (CVD).
Recent studies indicate that blood from young mice reduces age-associated pathologies …

Adipose tissue (AT) secretes several adipokines that influence insulin sensitivity and
potentially link obesity to insulin resistance. Apelin, a peptide present in different tissues, is …

The recently discovered peptide apelin is known to be involved in the maintenance of insulin
sensitivity. However, questions persist regarding its precise role in the chronic setting …

Cardiac hypertrophy is initiated as an adaptive response to sustained overload but
progresses pathologically as heart failure ensues. Here we report that genetic loss of APJ, a …

It has been recently recognized that the increased oxidative stress (ROS overproduction) in
obese condition is a key contributor to the pathogenesis of obesity-associated metabolic …

Apelin is a bioactive peptide known as the ligand of the G protein-coupled receptor APJ.
Diverse active apelin peptides exist under the form of 13, 17 or 36 amino acids, originated …

Insulin resistance is a main feature of obesity and type 2 diabetes mellitus (T2DM). Several
mechanisms linking obesity to insulin resistance have been proposed. Adipose tissue …

Apelin is the endogenous ligand for the previously orphaned G protein-coupled receptor,
APJ. This novel peptidic signalling pathway is widely represented in the heart and …