The limbic system has consistently been associated with the control of emotions and with
mood disorders. The goal of this study was to identify new molecular targets associated with …

Mood disorders are a major cause of disability. Etiology includes genetic and environmental
factors, but the responsible genes have yet to be identified. Using DNA microarrays, we …

The prefrontal cortex is believed to play a major role in depression and suicidal behavior
through regulation of cognition, memory, recognition of emotion, and anxiety-like states, with …

Background Most studies investigating the neurobiology of depression and suicide have
focused on the serotonergic system. While it seems clear that serotonergic alterations play a …

Molecular mechanisms behind the etiology and pathophysiology of major depressive
disorder and suicide remain largely unknown. Recent molecular studies of expression of …

Background Suicide is an important and potentially preventable consequence of serious
mental disorders of unknown etiology. Gene expression profiling technology provides an …

Objectives. Suicide is partly heritable but the responsible genes have not been identified.
We conducted a gene-centric, low coverage single nucleotide polymorphism (SNP) pilot …

Suicidal behaviors are frequent in mood disorders patients but only a subset of them ever
complete suicide. Understanding predisposing factors for suicidal behaviors in high risk …

Brain gene expression profiling studies of suicide and depression using oligonucleotide
microarrays have often failed to distinguish these two phenotypes. Moreover, next …

The neurobiological basis of suicidal behaviour is multifactorial and complex. Several lines
of evidence indicate that environmental factors as well as multiple genes and interactions of …