Anticoagulant macromolecules have gained widespread use in the clinical treatment of
cardiovascular diseases, blood-contacting or implantable materials, and medical devices …

Coagulation is a potential defense mechanism that involves activating a series of zymogens
to convert soluble fibrinogen to insoluble fibrin clots to prevent bleeding and hemorrhagic …

Clinically used anticoagulants are inhibitors of enzymes involved in the coagulation
pathway, primarily thrombin and factor Xa. These agents can be either direct or indirect …

Recently, we designed sulfated dehydropolymers (DHPs) of 4-hydroxycinnamic acids that
displayed interesting anticoagulant properties. Structurally and mechanistically, sulfated …

Severe hemorrhage has posed a serious threat to the health and even life of civilian and
military populations and brought serious economic losses. Consequently, it is imperative to …

During the past decade, remarkable progress has been made in the development of new
drugs to treat thrombotic and cardiovascular diseases, the number one cause of mortality …

Globally, thrombosis-associated disorders are one of the main contributors to fatalities.
Besides genetic influences, there are some acquired and environmental risk factors …

Hemorrhage is a potentially life-threatening emergency that can occur at any time or place.
Whether traumatic, congenital, surgical, disease-related, or drug-induced, bleeding can lead …

Heparin and its low molecular weight derivatives are clinical therapeutics used to treat and
prevent blood clots, but are prone to side effects and contamination. Here we describe the …

Thrombosis is the condition where an imbalance in the homeostatic mechanism results in
unwanted intravascular thrombus formation. Imbalances in this highly regulated process of …