Cardiac induction in Drosophila relies on combinatorial Dpp and Wg signaling activities that
are derived from the ectoderm. Although some of the actions of Dpp during this process …

Cell fate decisions are driven through the integration of inductive signals and tissue-specific
transcription factors (TFs), although the details on how this information converges in cis …

Tbx20-related T-box genes have been implicated in the regulation of heart development in
several vertebrate species. In the present report, we demonstrate that a pair of genes …

Two secreted signaling molecules, wingless (wg) and decapentaplegic (dpp), are required
to specify the heart in Drosophila. wg and dpp are also required to specify other cell types …

The Drosophila melanogaster genes midline and H15 encode predicted T-box transcription
factors homologous to vertebrate Tbx20 genes. All identified vertebrate Tbx20 genes are …

Publisher Summary Recently, some of the genetic mechanisms of heart specification have
been elucidated in Drosophila. This chapter summarizes the functions and interactions of …

The embryonic heart precursors of Drosophila are arranged in a repeated pattern of
segmental units. There is growing evidence that the development of individual elements of …

The Drosophila heart consists of two major cell types: cardioblasts, which form the
contractile tube of the heart; and pericardial cells, which flank the cardioblasts and are …

Mesoderm induction has been studied in many systems and some of the factors involved
have been identified. Although the heart is mesodermal in origin, the molecular basis of …

Inductive signaling is of pivotal importance for developmental patterns to form. In Drosophila,
the transfer of TGFβ (Dpp) and Wnt (Wg) signaling information from the ectoderm to the …