DOCK family proteins: key players in immune surveillance mechanisms
K Kunimura, T Uruno, Y Fukui - International immunology, 2020 - academic.oup.com
Dedicator of cytokinesis (DOCK) proteins constitute a family of evolutionarily conserved
guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK …
guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK …
Immune regulatory functions of DOCK family proteins in health and disease
A Nishikimi, M Kukimoto-Niino, S Yokoyama… - Experimental cell …, 2013 - Elsevier
DOCK proteins constitute a family of evolutionarily conserved guanine nucleotide exchange
factors (GEFs) for Rho family of GTPases. Although DOCK family proteins do not contain the …
factors (GEFs) for Rho family of GTPases. Although DOCK family proteins do not contain the …
DOCK8 regulates signal transduction events to control immunity
CJ Kearney, KL Randall, J Oliaro - Cellular & molecular immunology, 2017 - nature.com
Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of
hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 …
hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 …
DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs
Retinoic acid receptor-related orphan receptor-γt-positive (RORγt+) innate lymphoid cells
(ILCs) produce interleukin (IL)-22 and IL-17, which are critical for protective immunity against …
(ILCs) produce interleukin (IL)-22 and IL-17, which are critical for protective immunity against …
DOCK8 is essential for T‐cell survival and the maintenance of CD8+ T‐cell memory
T Lambe, G Crawford, AL Johnson… - European journal of …, 2011 - Wiley Online Library
Deficiency in the guanine nucleotide exchange factor dedicator of cytokinesis 8 (DOCK8)
causes a human immunodeficiency syndrome associated with recurrent sinopulmonary and …
causes a human immunodeficiency syndrome associated with recurrent sinopulmonary and …
DOCK8 deficiency: insights into pathophysiology, clinical features and management
Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency
that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending …
that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending …
Structural insights into the small GTPase specificity of the DOCK guanine nucleotide exchange factors
M Kukimoto-Niino, K Ihara, K Murayama… - Current Opinion in …, 2021 - Elsevier
The dedicator of cytokinesis (DOCK) family of guanine nucleotide exchange factors (GEFs)
regulates cytoskeletal dynamics by activating the GTPases Rac and/or Cdc42. Eleven …
regulates cytoskeletal dynamics by activating the GTPases Rac and/or Cdc42. Eleven …
Dock2 in the development of inflammation and cancer
Y Chen, F Meng, B Wang, L He… - European journal of …, 2018 - Wiley Online Library
An atypical guanine exchange factor, Dock2 is specifically expressed in hematopoietic cells
and regulates activation and migration of immune cells through activating Ras‐related C3 …
and regulates activation and migration of immune cells through activating Ras‐related C3 …
Human DOCK2 deficiency: report of a novel mutation and evidence for neutrophil dysfunction
L Moens, M Gouwy, B Bosch, O Pastukhov… - Journal of clinical …, 2019 - Springer
DOCK2 is a guanine-nucleotide-exchange factor for Rac proteins. Activated Rac serves
various cellular functions including the reorganization of the actin cytoskeleton in …
various cellular functions including the reorganization of the actin cytoskeleton in …
Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors
DOCK (dedicator of cytokinesis) guanine nucleotide exchange factors (GEFs) activate the
Rho-family GTPases Rac and Cdc42 to control cell migration, morphogenesis, and …
Rho-family GTPases Rac and Cdc42 to control cell migration, morphogenesis, and …