The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

Investigating human development is a substantial scientific challenge due to the technical
and ethical limitations of working with embryonic samples. In the face of these difficulties …

Embryonic stem (ES) cells are derived from blastocyst-stage embryos and are thought to be
functionally equivalent to the inner cell mass, which lacks the ability to produce all …

Recently, several studies using cultures of human embryos together with single-cell RNA-
seq analyses have revealed differences between humans and mice, necessitating the study …

Human pluripotent and trophoblast stem cells have been essential alternatives to
blastocysts for understanding early human development 1, 2, 3, 4. However, these simple …

One week after fertilization, human embryos implant into the uterus. This event requires the
embryo to form a blastocyst consisting of a sphere encircling a cavity lodging the embryo …

Limited access to embryos has hampered the study of human embryogenesis and disorders
that occur during early pregnancy. Human pluripotent stem cells provide an alternative …

Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and
the germline but are excluded from the extra-embryonic tissues that are derived from the …

The application of human embryonic stem (ES) cells in medicine and biology has an
inherent reliance on understanding the starting cell population. Human ES cells differ from …

The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …