Template switching and duplications in SARS-CoV-2 genomes give rise to insertion variants that merit monitoring

SK Garushyants, IB Rogozin, EV Koonin - Communications biology, 2021 - nature.com
The appearance of multiple new SARS-CoV-2 variants during the COVID-19 pandemic is a
matter of grave concern. Some of these variants, such as B. 1.617. 2, B. 1.1. 7, and B. 1.351 …

Conserved pattern and potential role of recurrent deletions in SARS-CoV-2 evolution

S Weng, H Zhou, C Ji, L Li, N Han, R Yang… - Microbiology …, 2022 - Am Soc Microbiol
ABSTRACT SARS-CoV-2 continues adapting to human hosts during the current worldwide
pandemic since 2019. This virus evolves through multiple means, such as single nucleotide …

Emergence of genomic diversity and recurrent mutations in SARS-CoV-2

L Van Dorp, M Acman, D Richard, LP Shaw… - Infection, Genetics and …, 2020 - Elsevier
SARS-CoV-2 is a SARS-like coronavirus of likely zoonotic origin first identified in December
2019 in Wuhan, the capital of China's Hubei province. The virus has since spread globally …

Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants

R Wang, J Chen, K Gao, Y Hozumi, C Yin… - Communications …, 2021 - nature.com
SARS-CoV-2 has been mutating since it was first sequenced in early January 2020. Here,
we analyze 45,494 complete SARS-CoV-2 geneome sequences in the world to understand …

Deletions across the SARS-CoV-2 genome: molecular mechanisms and putative functional consequences of deletions in accessory genes

IB Rogozin, A Saura, A Bykova, V Brover, V Yurchenko - Microorganisms, 2023 - mdpi.com
The analysis of deletions may reveal evolutionary trends and provide new insight into the
surprising variability and rapidly spreading capability that SARS-CoV-2 has shown since its …

SARS-CoV-2 variant evolution in the United States: High accumulation of viral mutations over time likely through serial Founder Events and mutational bursts

RN Tasakis, G Samaras, A Jamison, M Lee, A Paulus… - PLoS …, 2021 - journals.plos.org
Since the first case of COVID-19 in December 2019 in Wuhan, China, SARS-CoV-2 has
spread worldwide and within a year and a half has caused 3.56 million deaths globally. With …

High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19

SH Ko, E Bayat Mokhtari, P Mudvari, S Stein… - PLoS …, 2021 - journals.plos.org
Tracking evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
within infected individuals will help elucidate coronavirus disease 2019 (COVID-19) …

Emergence and evolution of a prevalent new SARS-CoV-2 variant in the United States

AA Pater, MS Bosmeny, CL Barkau, KN Ovington… - BioRxiv, 2021 - biorxiv.org
Genomic virus surveillance can lead to early identification of new variants and inform proper
response during a pandemic. Using this approach, we have identified a new variant of the …

[HTML][HTML] Signal hotspot mutations in SARS-CoV-2 genomes evolve as the virus spreads and actively replicates in different parts of the world

S Weber, C Ramirez, W Doerfler - Virus research, 2020 - Elsevier
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was first
identified in Wuhan, China late in 2019. Nine months later (Sept. 23, 2020), the virus has …

Analysis of emerging variants in structured regions of the SARS-CoV-2 genome

SP Ryder, BR Morgan, P Coskun… - Evolutionary …, 2021 - journals.sagepub.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
motivated a widespread effort to understand its epidemiology and pathogenic mechanisms …