An enhanced understanding of the importance of Janus kinase (JAK) and signal transducer
and activator of transcription (STAT) signalling in multiple disease states has led to an …

Abstract The European Journal of Immunology was launched 50 years ago, coinciding with
the discovery of many cytokines and growth factors and the emergence of an entirely new …

Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a
consequence they play pivotal roles in the patho-physiology of many diseases including …

The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

Altered production of cytokines can result in pathologies ranging from autoimmune diseases
to malignancies. The Janus kinase family is a small group of receptor-associated signaling …

Janus kinases (JAKs) are required for cytokine receptor signaling. Since the discovery of the
highly prevalent JAK2 V617F mutation in myeloproliferative neoplasms (MPNs), JAK2 …

In this era, it is axiomatic that cytokines have critical roles in cellular development and
differentiation, immune homeostasis, and host defense. Equally, dysregulation of cytokines …

Janus kinase (JAK) inhibitors (jakinibs) that target downstream signalling by a large range of
cytokines are effective in treating autoimmune and rheumatic diseases. Newer jakinibs that …

Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting
cytokines and cytokine receptors with biologics has revolutionized the treatment of many of …

The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non‐
receptor protein tyrosine kinases. They are involved in cell growth, survival, development …