A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotypes

M Chevillotte, J von Einem, BM Meier, FM Lin… - Antiviral research, 2010 - Elsevier
Drug resistant strains of human cytomegalovirus (HCMV) in patients at risk may increasingly
develop into a problem in the clinical setting. Genotypic resistance testing is becoming the …

The genetic basis of human cytomegalovirus resistance and current trends in antiviral resistance analysis

SH James, MN Prichard - Infectious Disorders-Drug Targets …, 2011 - ingentaconnect.com
Infections due to resistant human cytomegalovirus (CMV) are an emerging problem,
particularly in immunocompromised hosts. When managing such patients, clinicians should …

The biology of cytomegalovirus drug resistance

M Hakki, S Chou - Current opinion in infectious diseases, 2011 - journals.lww.com
An increasing volume of information correlating CMV genotypes and drug susceptibility
phenotypes is becoming available. This will improve the interpretation of sequence-based …

Antiviral drug resistance in human cytomegalovirus

S Chou - Transplant infectious disease, 1999 - Wiley Online Library
Drug‐resistant cytomegalovirus (CMV) should be considered when viral shedding persists
after several weeks of therapy. The problem is most likely to arise in the setting of a severely …

Antiviral drug resistance of human cytomegalovirus

NS Lurain, S Chou - Clinical microbiology reviews, 2010 - Am Soc Microbiol
The study of human cytomegalovirus (HCMV) antiviral drug resistance has enhanced
knowledge of the virological targets and the mechanisms of antiviral activity. The currently …

Novel method based on “en passant” mutagenesis coupled with a Gaussia luciferase reporter assay for studying the combined effects of human cytomegalovirus …

E Drouot, J Piret, G Boivin - Journal of clinical microbiology, 2013 - Am Soc Microbiol
Human cytomegalovirus (HCMV) resistance to antivirals is a major problem in
immunocompromised patients. Drug resistance is characterized by phenotypic testing or …

Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from …

T Cihlar, MD Fuller, JM Cherrington - Journal of virology, 1998 - Am Soc Microbiol
ABSTRACT A number of specific point mutations in the human cytomegalovirus (HCMV)
DNA polymerase (UL54) gene have been tentatively associated with decreased …

Clinical and biologic aspects of human cytomegalovirus resistance to antiviral drugs

F Baldanti, N Lurain, G Gerna - Human immunology, 2004 - Elsevier
The emergence of human cytomegalovirus (HCMV) drug resistant strains is a life-
threatening condition in immunocompromised individuals with active HCMV infection …

Detection of cytomegalovirus drug resistance mutations by next-generation sequencing

MK Sahoo, MI Lefterova, F Yamamoto… - Journal of clinical …, 2013 - Am Soc Microbiol
Antiviral therapy for cytomegalovirus (CMV) plays an important role in the clinical
management of solid organ and hematopoietic stem cell transplant recipients. However …

Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance

S Chou - Antiviral research, 2020 - Elsevier
Cytomegalovirus (CMV) drug resistance mutation maps are updated with recent information
for polymerase inhibitors, the terminase inhibitor letermovir and the UL97 kinase inhibitor …