We used the 10x Genomics Visium platform to define the spatial topography of gene
expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive …

Gene expression levels vary across developmental stage, cell type, and region in the brain.
Genomic variants also contribute to the variation in expression, and some neuropsychiatric …

Brain function is governed by precise regulation of gene expression across its anatomically
distinct structures; however, the expression patterns of genes across hundreds of brain …

Neuroanatomically precise, genome-wide maps of transcript distributions are critical
resources to complement genomic sequence data and to correlate functional and genetic …

Recent advances in spatial transcriptomics (ST) have brought unprecedented opportunities
to understand tissue organization and function in spatial context. However, it is still …

Transcriptome analysis of human brain provides fundamental insight into development and
disease, but it largely relies on existing annotation. We sequenced transcriptomes of 72 …

Spatially charting molecular cell types at single-cell resolution across the 3D volume is
critical for illustrating the molecular basis of brain anatomy and functions. Single-cell RNA …

The human brain is comprised of a complex web of functional networks that link
anatomically distinct regions. However, the biological mechanisms supporting network …

To characterize gene expression patterns in the regional subdivisions of the mammalian
brain, we integrated spatial gene expression patterns from the Allen Brain Atlas for the adult …

The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types and their …