The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of
the brain of hydrophilic solutes unable to cross the blood–brain barrier. It suggests that there …

Background Transport of solutes has been observed in the spaces surrounding cerebral
arteries and veins. Indeed, transport has been found in opposite directions in two different …

Normal physiologic function of organs requires a circulation of interstitial fluid to deliver
nutrients and clear cellular waste products. Lymphatic vessels serve as collectors of this fluid …

This review considers efflux of substances from brain parenchyma quantified as values of
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …

We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in
recent years, highlighted that fluid is directionally transported within the central nervous …

Identification of the perivascular compartment as the point of exchange between
cerebrospinal fluid (CSF) and interstitial fluid mediating solute clearance in the brain, named …

Brain fluids are rigidly regulated to provide stable environments for neuronal function, eg,
low K+, Ca 2+, and protein to optimise signalling and minimise neurotoxicity. At the same …

Tracers injected into CSF pass into the brain alongside arteries and out again. This has
been recently termed the “glymphatic system” that proposes tracers enter the brain along …

Interstitial fluid (ISF) surrounds the parenchymal cells of the brain and spinal cord while
cerebrospinal fluid (CSF) fills the larger spaces within and around the CNS. Regulation of …