The recent discovery of new potent therapeutic molecules that do not reach the clinic due to
poor delivery and low bioavailability have made of delivery a key stone in therapeutic …

The recent discovery of new potent therapeutic molecules that do not reach the clinic due to
poor delivery and low bioavailability has made of delivery a keystone in therapeutic …

Cell-penetrating peptides (CPPs) are short peptides of less than 30 amino acids that are
able to penetrate cell membranes and translocate different cargoes into cells. The only …

The selective permeability of the plasma membrane prohibits most exogenous agents from
gaining cellular access. Since many therapeutics and reporter molecules must be …

Cell-penetrating compounds are substances that enhance the cellular uptake of various
molecular cargoes that do not easily cross the cellular membrane. The majority of cell …

Despite continuing advances in the development of macromolecules, including peptides,
proteins, and oligonucleotides, for therapeutic purposes, the successful application of these …

The main problem of therapeutic efficiency lies in the crossing of cellular membranes.
Therefore, significant effort is being made to develop agents which can cross these barriers …

The recent discovery of new potent therapeutic molecules which do not reach the clinic due
to poor delivery and low bioavailability have made the delivery of molecules a keystone in …

The cell membrane poses a substantial hurdle to the use of pharmacologically active
biomacromolecules that are not per se actively translocated into cells. An appealing …

A major obstacle in the development of new therapeutic agents is the low bioavailability of
hydrophilic substances. Drugs that bind to intracellular targets must penetrate the lipid …