After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as
discrete epigenetic changes, that can dictate both ongoing and future inflammatory …

Macrophages are crucial in the progression of atherosclerotic cardiovascular disease
(ASCVD). In the atherosclerotic lesions, macrophages play a central role in maintaining …

Atherosclerosis is characterized by chronic low grade inflammation of arteries that results in
the development of lipid dense plaques. Chronic inflammation induced by Western-type diet …

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …

Macrophage immunometabolism, the changes in intracellular metabolic pathways that alter
the function of these highly plastic cells, has been the subject of intense interest in the past …

A key aspect of atherosclerosis is the maladaptive inflammatory response to lipoprotein
accumulation in the artery. The failure to decrease lipid accumulation, to clear apoptotic …

Atherosclerosis is a chronic inflammatory disease and a leading cause of human mortality.
The lesional microenvironment contains a complex accumulation of variably oxidized lipids …

Macrophages are becoming increasingly recognized as key agents in chronic diseases of
aging, including cancer, metabolic disease, and, the topic of this review, atherosclerosis. In …

Macrophages orchestrate the inflammatory response in inflamed tissues, and recent work
indicates that these cells can alter their phenotypes and functions accordingly in response to …

Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid
metabolism and a maladaptive immune response driven by the accumulation of cholesterol …