Clinical and experimental data suggest that pathogenesis in anti-neutrophil cytoplasmic
antibody (ANCA)-associated vasculitis is driven by ANCA-mediated activation of neutrophils …

Anti-neutrophil cytoplasmic antibody (ANCA) vasculitis is characterized by the presence of
autoantibodies to myeloperoxidase and proteinase-3, which bind monocytes in addition to …

Anti-neutrophil cytoplasmic antibodies (ANCA) are thought to be pathogenic in ANCA-
associated vasculitis (AAV) by stimulating polymorphonuclear leucocytes (PMNs) to …

ANCA-associated vasculitis (AAV) is a severe systemic autoimmune disease. A key feature
of AAV is the presence of Anti-Neutrophil Cytoplasmic Antibodies (ANCA) directed against …

ANCA vasculitis encompasses several autoimmune conditions characterised by destruction
of small vessels, inflammation of the respiratory tract and glomerulonephritis. Most patients …

Necrotizing, small-vessel vasculitis develops in patients with circulating ANCAs. Neutrophils
and monocytes harbor the two major ANCA antigens, PR3 and MPO. A whole body of in …

The discovery of anti-neutrophil cytoplasmic antibodies (ANCA) and their antigenic targets,
myeloperoxidase (MPO) and proteinase 3 (PR3), has led to further understanding as to the …

The inflammation of blood vessel walls that is associated with autoimmune disorders
characterized by anti‐neutrophil cytoplasm antibodies (ANCA) represents dysregulation of …

In systemic vasculitis, interactions between antineutrophil cytoplasm autoantibodies
(ANCAs) and neutrophils initiate endothelial and vascular injury. ANCAs directed against …

ANCA-induced activation of both neutrophils and monocytes is one of the main pathogenic
mechanisms involved in disease induction. Therefore, a better understanding of the …