Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

A series of 1-acylamino boronic acids (IA-VA), analogues of the amino acids phenylalanine,
phenylglycine, alanine, valine, and isoleucine, were prepared as potential transition-state …

Boron compounds have been used extensively in organic synthesis for more than sixty
years. Some of the best known organic reactions such as hydroboration and the Suzuki …

The four major classes of protease enzymes1-4 (aspartic, serine, cysteine, and metallo)
selectively catalyze the hydrolysis of polypeptide bonds. Their control over protein synthesis …

Roger Bone, § Dan Frank, § Charles A. Kettner, 11 and David A. Agard*'§ Department of
Biochemistry and Biophysics and The Howard Hughes Medical Institute, University of …

This review includes a personal account of the history of the development of the α‐amido
boronic acid synthesis and related chemistry in the author's laboratory, as well as a review of …

Boronic acid compounds have been used, because of their unique structural features, for the
development of potent enzyme inhibitors, boron neutron capture agents for cancer therapy …

Proteases or proteolytic enzymes form one of the largest and more important groups of
enzymes. Proteases selectively catalyze the hydrolysis of peptide bonds and can be divided …

Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. As
compared to peptidyl aldehyde compounds, boronic acids in this series display dramatically …

The use of boron in small-molecule pharmaceuticals is increasing. Boron's ubiquitous
occurrence in nature and the recent success of a boronic acid drug (Velcade®) in the clinic …