Alzheimer's disease is characterized by 2 pathological proteins, amyloid beta 42 and tau.
The majority of Alzheimer's disease cases in the population are sporadic and late-onset …

We have leveraged a Drosophila model relevant to Alzheimer disease (AD) for functional
screening of findings from a genome-wide scan for loci associated with a quantitative …

Using a Drosophila model of Alzheimer's disease (AD), we systematically evaluated 67
candidate genes based on AD-associated genomic loci (P< 10− 4) from published human …

Abstract Purpose of Review The advent of genome-wide association studies (GWASs)
constituted a breakthrough in our understanding of the genetic architecture of multifactorial …

The accumulation of amyloid β peptide (Aβ) in the brain of Alzheimer's disease (AD) patients
begins many years before clinical onset. Such process has been proposed to be pathogenic …

Sustained increases in life expectancy have underscored the importance of managing
diseases with a high incidence in late life, such as various neurodegenerative conditions …

Polygenic risk scores have identified that genetic variants without genome‐wide significance
still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how …

Genetic studies have demonstrated very high heritability for Alzheimer's disease (AD) risk in
humans; however, these genetic contributions have proven extremely challenging to map in …

Alzheimer's disease (AD) is the leading cause of dementia and the most common
neurodegenerative disorder. AD is mostly a sporadic disorder and its main risk factor is age …

As a group, strains of laboratory mice carrying Alzheimer's disease (AD)-related transgenes
are currently the most widely studied animal models of AD. Many AD mouse models carrying …