The discovery of group 2 innate lymphoid cells has changed the concept of type 2 immune diseases

T Kobayashi, Y Motomura, K Moro - International immunology, 2021 - academic.oup.com
Group 2 innate lymphoid cells (ILC2s), discovered in 2010, have been recognized as
immune cells with unique functions and their involvement in various diseases has been …

Tissue-specific diversity of group 2 innate lymphoid cells in the skin

T Kobayashi, K Moro - Frontiers in Immunology, 2022 - frontiersin.org
Since the discovery of group 2 innate lymphoid cells (ILC2s), their developmental pathways,
mechanisms of activation and regulation, and immunological roles in the steady state and in …

Characteristics of innate lymphoid cells (ILCs) and their role in immunological disorders (an update)

R Yazdani, M Sharifi, AS Shirvan, G Azizi… - Cellular …, 2015 - Elsevier
Innate lymphoid cells (ILCs) are a novel family of hematopoietic effectors and regulators of
innate immunity. Although these cells are morphologically similar to B cells and T cells …

Group 2 innate lymphoid cells in disease

TYF Halim - International immunology, 2016 - academic.oup.com
Group 2 innate lymphoid cells (ILC2) are now recognized as an important innate source of
type-2 effector cytokines. Although initially associated with mucosal tissues, it is clear that …

Type 2 innate lymphoid cells in allergic disease

S Lund, HH Walford, TA Doherty - Current immunology …, 2013 - ingentaconnect.com
Type II innate lymphoid cells (ILC2) are a novel population of lineage-negative cells that
produce high levels of Th2 cytokines IL-5 and IL-13. ILC2 are found in human respiratory …

Heterogeneity of type 2 innate lymphoid cells

H Spits, J Mjösberg - Nature Reviews Immunology, 2022 - nature.com
More than a decade ago, type 2 innate lymphoid cells (ILC2s) were discovered to be
members of a family of innate immune cells consisting of five subsets that form a first line of …

Transcription factors in the development and function of group 2 innate lymphoid cells

T Ebihara, I Taniuchi - International journal of molecular sciences, 2019 - mdpi.com
Group 2 innate lymphoid cells (ILC2s) are tissue-resident cells and are a major source of
innate TH2 cytokine secretion upon allergen exposure or parasitic-worm infection …

The role of type 2 innate lymphoid cells in allergic diseases

H Zheng, Y Zhang, J Pan, N Liu, Y Qin, L Qiu… - Frontiers in …, 2021 - frontiersin.org
Allergic diseases are significant diseases that affect many patients worldwide. In the past
few decades, the incidence of allergic diseases has increased significantly due to …

Type-2 innate lymphoid cells in human allergic disease

JL Barlow, ANJ McKenzie - Current opinion in allergy and clinical …, 2014 - journals.lww.com
It is essential that alongside the mechanistic investigation using model organisms, the roles
of ILC2s in human disease be explored. Here, we discuss how ILC2 traits, discovered in …

At the bedside: the emergence of group 2 innate lymphoid cells in human disease

RS Peebles - Journal of Leucocyte Biology, 2015 - academic.oup.com
ILC2s have been primarily identified at environmental-mucosal interfaces and can be
activated quickly by environmental antigens and pathogens to produce large quantities of IL …