In experimental studies in the dog, total proximal coronary artery occlusions of up to 15
minutes result in reversible injury, meaning that the myocytes survive this insult. The 15 …

Conclusions In conclusion, there are two phases of ischemic preconditioning against
stunning: an early phase (which begins within minutes) and a late phase (which begins …

We have recently found in conscious pigs that a sequence of brief coronary occlusions
induces severe myocardial stunning, but when the same sequence is repeated 24 hours …

Ischemic preconditioning, a powerful form of endogenous protection against myocardial
infarction, has been demonstrated in several animal species and, recently, in isolated …

Ischemic preconditioning offers powerful protection from ischemie necrosis in a wide range
of animal species, but does it occur in humans? Support for preconditioning in humans …

On July 2–3, 1996, the National Heart, Lung, and Blood Institute sponsored a workshop in
Columbia, Md, entitled “The Medical and Cellular Implications of Myocardial Stunning …

BACKGROUND Despite numerous reports that one or more episodes of brief coronary
artery occlusion preconditions the myocardium and dramatically reduces myocardial infarct …

Background In the experimental setting, it has been demonstrated that preconditioning
myocardium before prolonged occlusion with brief ischemic episodes affords substantial …

Preconditioning myocardium with brief episodes of ischemia reduces energy demand and
delays cell death during a subsequent ischemic episode. We hypothesized that …

Among the numerous mechanisms proposed for myocardial stunning, three appear to be
more plausible: 1) generation of oxygen radicals, 2) calcium overload, and 3) excitation …