Mycosis fungoides (MF) is the most frequent manifestation of cutaneous T cell lymphoma but
its cause and pathophysiology remain unclear. Because progression of lesions is …

Abstract Fas (APO-1/CD95) is a transmembrane protein which mediates programmed cell
death (apoptosis). Cells with a mutated Fas gene are resistant to apoptosis and thus …

Background Low proliferation rates, sparse apoptotic cells, and resistance to
chemotherapeutic agents suggest that defective apoptotic mechanisms may be important in …

Mycosis fungoides and its leukemic variant, Sézary syndrome, represent the most common
forms of cutaneous T cell lymphomas (CTCL). These disorders are clonal neoplasms …

Defective apoptosis signaling has been implicated in the pathogenesis of primary cutaneous
T-cell lymphomas (CTCLs), a group of malignancies derived from skin-homing T cells. An …

FAS expression was generally low in 30 of 31 cutaneous T-cell lymphoma (CTCL) cases
(mycosis fungoides/Sezary syndrome, SS) as well as in 5 of 6 large plaque parapsoriasis …

Abstract Background Fas (CD95; APO‐1) is a transmembrane protein that mediates
apoptosis upon cross‐linking with Fas‐ligand (Fas‐L). Interaction of Fas‐L expressed by …

Background The usually protracted and indolent course of cutaneous T‐cell lymphoma
(CTCL) is consistent with an accumulation of lymphocytes rather than being a true …

FAS (TNF receptor superfamily member 6, also known as CD95) plays a major role in T-cell
apoptosis and is often dysregulated in CTCL. We searched for structural alterations of the …

The molecular mechanisms by which advanced cases of cutaneous T cell lymphoma
(CTCL)(mycosis fungoides/Sezary syndrome) undergo large cell transformation (LCT) and …