The tissues of the central nervous system are effectively shielded from the blood circulation
by specialized vessels that are impermeable not only to cells, but also to most …

The blood–brain barrier (BBB) and the environment of the central nervous system (CNS)
guard the nervous tissue from peripheral immune cells. In the autoimmune disease multiple …

In multiple sclerosis, brain-reactive T cells invade the central nervous system (CNS) and
induce a self-destructive inflammatory process. T-cell infiltrates are not only found within the …

We tracked pathogenic myelin basic protein-specific CD4+ effector T cells in early central
nervous system (CNS) lesions of experimental autoimmune encephalomyelitis (EAE) by …

T lymphocytes specific for myelin basic protein (MBP) are responsible for the cellular events
leading to autoimmune disease within the central (CNS) and peripheral (PNS) nervous …

Lymphocytic choriomeningitis virus infection of the mouse central nervous system (CNS)
elicits fatal immunopathology through blood–brain barrier breakdown and convulsive …

Immunization with myelin antigens leads to the development of experimental autoimmune
encephalomyelitis, an animal model of multiple sclerosis. The disease can also be induced …

Circulating antibodies can access most tissues to mediate surveillance and elimination of
invading pathogens. Immunoprivileged tissues such as the brain and the peripheral nervous …

Astrocyte proliferation and perivascular lymphocyte infiltration are conspicuous among the
cellular changes in the active brain lesions of multiple sclerosis patients1. Recent …

Immune surveillance against pathogens and tumours in the central nervous system is
thought to be limited owing to the lack of lymphatic drainage. However, the characterization …