[HTML][HTML] An effective CTL peptide vaccine for Ebola Zaire Based on Survivors' CD8+ targeting of a particular nucleocapsid protein epitope with potential implications …

CV Herst, S Burkholz, J Sidney, A Sette, PE Harris… - Vaccine, 2020 - Elsevier
Abstract The 2013–2016 West Africa EBOV epidemic was the biggest EBOV outbreak to
date. An analysis of virus-specific CD8+ T-cell immunity in 30 survivors showed that 26 of …

Analysis of CD8+ T cell response during the 2013–2016 Ebola epidemic in West Africa

S Sakabe, BM Sullivan, JN Hartnett… - Proceedings of the …, 2018 - National Acad Sciences
The recent Ebola epidemic exemplified the importance of understanding and controlling
emerging infections. Despite the importance of T cells in clearing virus during acute …

[HTML][HTML] Computational prediction and identification of HLA-A2. 1-specific Ebola virus CTL epitopes

K Sundar, A Boesen, R Coico - Virology, 2007 - Elsevier
Ebola virus (EBOV) is known to cause a severe hemorrhagic fever resulting in high mortality.
Although the precise host defense mechanism (s) that afford protection against EBOV is not …

Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins

S Wu, T Yu, X Song, S Yi, L Hou, W Chen - Virology Journal, 2012 - Springer
Abstract Background Ebola viruses (EBOVs) cause severe hemorrhagic fever with a high
mortality rate. At present, there are no licensed vaccines or efficient therapies to combat …

Matrix-M adjuvant enhances antibody, cellular and protective immune responses of a Zaire Ebola/Makona virus glycoprotein (GP) nanoparticle vaccine in mice

KL Bengtsson, H Song, L Stertman, Y Liu, DC Flyer… - Vaccine, 2016 - Elsevier
Ebola virus (EBOV) causes severe hemorrhagic fever for which there is no approved
treatment or preventive vaccine. Immunological correlates of protective immunity against …

A synthetic peptide CTL vaccine targeting nucleocapsid confers protection from SARS-CoV-2 challenge in rhesus macaques

PE Harris, T Brasel, C Massey, CV Herst, S Burkholz… - Vaccines, 2021 - mdpi.com
Background: Persistent transmission of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has given rise to a COVID-19 pandemic. Several vaccines, conceived in …

Transcriptomic analysis reveals a previously unknown role for CD8+ T-cells in rVSV-EBOV mediated protection

AR Menicucci, S Sureshchandra, A Marzi… - Scientific reports, 2017 - nature.com
Ebola virus (EBOV) poses a significant threat to human health as highlighted by the recent
epidemic in West Africa. Data from animal studies and a ring vaccination clinical trial …

A Kunjin replicon virus-like particle vaccine provides protection against Ebola virus infection in nonhuman primates

OV Pyankov, SA Bodnev, OG Pyankova… - The Journal of …, 2015 - academic.oup.com
The current unprecedented outbreak of Ebola virus (EBOV) disease in West Africa has
demonstrated the urgent need for a vaccine. Here, we describe the evaluation of an EBOV …

Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection

KL Warfield, G Olinger, EM Deal… - The Journal of …, 2005 - journals.aai.org
Ebola virus (EBOV)-like particles (eVLP), composed of the EBOV glycoprotein and matrix
viral protein (VP) 40 with a lipid membrane, are a highly efficacious method of immunization …

A single dose of modified vaccinia Ankara expressing Ebola virus like particles protects nonhuman primates from lethal Ebola virus challenge

A Domi, F Feldmann, R Basu, N McCurley, K Shifflett… - Scientific Reports, 2018 - nature.com
Ebola virus (EBOV), isolate Makona, was the causative agent of the West African epidemic
devastating predominantly Guinea, Liberia and Sierra Leone from 2013–2016. While …