Vitamin B12, folate, and the methionine remethylation cycle—biochemistry, pathways, and regulation
DS Froese, B Fowler… - Journal of inherited …, 2019 - Wiley Online Library
Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …
Causes and consequences of impaired methionine synthase activity in acquired and inherited disorders of vitamin B12 metabolism
JL Guéant, RM Guéant-Rodriguez… - Critical reviews in …, 2022 - Taylor & Francis
Abstract Methyl-Cobalamin (Cbl) derives from dietary vitamin B12 and acts as a cofactor of
methionine synthase (MS) in mammals. MS encoded by MTR catalyzes the remethylation of …
methionine synthase (MS) in mammals. MS encoded by MTR catalyzes the remethylation of …
Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria
D Leclerc, A Wilson, R Dumas… - Proceedings of the …, 1998 - National Acad Sciences
Methionine synthase catalyzes the remethylation of homocysteine to methionine via a
reaction in which methylcobalamin serves as an intermediate methyl carrier. Over time, the …
reaction in which methylcobalamin serves as an intermediate methyl carrier. Over time, the …
Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene …
CM Dobson, T Wai, D Leclerc… - Proceedings of the …, 2002 - National Acad Sciences
Vitamin B12 (cobalamin) is an essential cofactor of two enzymes, methionine synthase and
methylmalonyl-CoA mutase. The conversion of the vitamin to its coenzymes requires a …
methylmalonyl-CoA mutase. The conversion of the vitamin to its coenzymes requires a …
A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins
Pathways for tailoring and processing vitamins into active cofactor forms exist in mammals
that are unable to synthesize these cofactors de novo. A prerequisite for intracellular …
that are unable to synthesize these cofactors de novo. A prerequisite for intracellular …
STRUCTURE-BASED PERSPECTIVES ON B12-DEPENDENT ENZYMES
ML Ludwig, RG Matthews - Annual review of biochemistry, 1997 - annualreviews.org
Two X-ray structures of cobalamin (B12) bound to proteins have now been determined.
These structures reveal that the B12 cofactor undergoes a major conformational change on …
These structures reveal that the B12 cofactor undergoes a major conformational change on …
Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation
Vitamin B 12 (cobalamin, Cbl) is essential to the function of two human enzymes, methionine
synthase (MS) and methylmalonyl-CoA mutase (MUT). The conversion of dietary Cbl to its …
synthase (MS) and methylmalonyl-CoA mutase (MUT). The conversion of dietary Cbl to its …
Deficiencies of folate and vitamin B6 exert distinct effects on homocysteine, serine, and methionine kinetics
GJ Cuskelly, PW Stacpoole… - American Journal …, 2001 - journals.physiology.org
Folate and vitamin B6 act in generating methyl groups for homocysteine remethylation, but
the kinetic effects of folate or vitamin B6 deficiency are not known. We used an intravenous …
the kinetic effects of folate or vitamin B6 deficiency are not known. We used an intravenous …
Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation
H Olteanu, R Banerjee - Journal of Biological Chemistry, 2001 - ASBMB
Methionine synthase is a key enzyme in the methionine cycle that catalyzes the
transmethylation of homocysteine to methionine in a cobalamin-dependent reaction that …
transmethylation of homocysteine to methionine in a cobalamin-dependent reaction that …
[HTML][HTML] Vitamin b-12
LH Allen - Advances in Nutrition, 2012 - ncbi.nlm.nih.gov
Vitamin B-12 is a cofactor for 2 enzymes. In the cytoplasm, methionine synthase requires
vitamin B-12 in the form of methylcobalamin and catalyzes the conversion of homocysteine …
vitamin B-12 in the form of methylcobalamin and catalyzes the conversion of homocysteine …