Chronic kidney disease: biomarker diagnosis to therapeutic targets

YN Wang, SX Ma, YY Chen, L Chen, BL Liu, QQ Liu… - Clinica Chimica …, 2019 - Elsevier
Chronic kidney disease (CKD), characterized as renal dysfunction, is recognized as a major
public health problem with high morbidity and mortality worldwide. Unfortunately, there are …

Metabolomics in chronic kidney disease

YY Zhao - Clinica chimica acta, 2013 - Elsevier
Chronic kidney disease (CKD) represents a major challenge to public healthcare.
Traditional clinical biomarkers of renal function (blood urea nitrogen and serum creatinine) …

Metabolomics in the study of kidney diseases

RH Weiss, K Kim - Nature Reviews Nephrology, 2012 - nature.com
Metabolomics—the nontargeted measurement of all metabolites produced by the body—is
beginning to show promise in both biomarker discovery and, in the form of …

Metabolomic signatures of chronic kidney disease of diverse etiologies in the rats and humans

ZH Zhang, H Chen, ND Vaziri, JR Mao… - Journal of proteome …, 2016 - ACS Publications
Chronic kidney disease (CKD) has emerged as a major public health problem worldwide. It
frequently progresses to end-stage renal disease, which is related to very high cost and …

Metabolomics approaches for the diagnosis and understanding of kidney diseases

H Abbiss, GL Maker, RD Trengove - Metabolites, 2019 - mdpi.com
Diseases of the kidney are difficult to diagnose and treat. This review summarises the
definition, cause, epidemiology and treatment of some of these diseases including chronic …

Metabolomics as a tool for the early diagnosis and prognosis of diabetic kidney disease

PR Pereira, DF Carrageta, PF Oliveira… - Medicinal Research …, 2022 - Wiley Online Library
Diabetic kidney disease (DKD) is one of the most prevalent comorbidities of diabetes
mellitus and the leading cause of the end‐stage renal disease (ESRD). DKD results from …

Metabolomics for clinical use and research in chronic kidney disease

B Hocher, J Adamski - Nature Reviews Nephrology, 2017 - nature.com
Chronic kidney disease (CKD) has a high prevalence in the general population and is
associated with high mortality; a need therefore exists for better biomarkers for diagnosis …

Metabolomics in diabetic kidney disease: unraveling the biochemistry of a silent killer

M Darshi, B Van Espen, K Sharma - American journal of nephrology, 2016 - karger.com
The development of new therapies for chronic diseases, such as diabetic kidney disease
(DKD), will continue to be hampered by lack of sufficient biomarkers that will provide insights …

Proteomics and metabolomics in kidney disease, including insights into etiology, treatment, and prevention

RF Dubin, EP Rhee - Clinical Journal of the American Society of …, 2020 - journals.lww.com
In this review of the application of proteomics and metabolomics to kidney disease research,
we review key concepts, highlight illustrative examples, and outline future directions. The …

New potential biomarkers for chronic kidney disease management—A review of the literature

I Lousa, F Reis, I Beirão, R Alves, L Belo… - International Journal of …, 2020 - mdpi.com
The prevalence of chronic kidney disease (CKD) is increasing worldwide, and the mortality
rate continues to be unacceptably high. The biomarkers currently used in clinical practice …