Background Aortic stiffness is an independent predictor of cardiovascular events in patients
with arterial hypertension. Resistant hypertension is often linked to hyperaldosteronism and …

Abstract Purpose of Review The purpose of the review is to examine whether measurement
of aortic stiffness could be especially value-adding for risk stratification and treatment among …

Abstract Background Some 10% to 15% of hypertensive patients have hyperaldosteronism,
an increased ambulant aldosterone-to-renin ratio. As aldosterone reduces arterial …

The present study is to investigate whether spironolactone is better than hydrochlorothiazide
(HCTZ) for blood pressure (BP) control and arterial stiffness improvement. Five-hundred …

Background Many studies proved the prognostic importance of aortic stiffness as an
independent predictor of cardiovascular morbidity and all-cause mortality. The decrease of …

Objectives: We sought to determine whether the addition of spironolactone to angiotensin-
converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) improves left …

OBJECTIVE: Excess aldosterone has a detrimental effect on large artery stiffness. We aimed
to investigate the association of the change in plasma aldosterone concentration (PAC) by …

Vascular damage is aggravated in animal models of hypertension with mineralocorticoid
(MR) excess and in hypertensive patients with primary hyperaldosteronism. MR antagonism …

The Prevention of Events with Angiotensin Converting Enzyme inhibition (PEACE) trial
evaluated angiotensin-converting enzyme inhibition with trandolapril versus placebo added …

Increased central arterial stiffness, involving accelerated vascular ageing of the aorta, is a
powerful and independent risk factor for early mortality and provides prognostic information …