Rhein is an anthraquinone compound isolated from the medicinal plant rhubarb and mainly
used in the clinical treatment of diabetic nephropathy. Rhein exhibits various renoprotective …

Renal fibrosis is the hallmark of chronic kidney diseases (CKD) and its development and
progression are significantly affected by epigenetic modifications. Rhein, a plant-derived …

Bone loss and increased fracture are the devastating outcomes of chronic kidney disease-
mineral and bone disorder (CKD-MBD) resulting from Klotho deficit-related mineral …

Renal fibrosis is a common histomorphological feature of renal aging and chronic kidney
diseases of all etiologies, and its initiation and progression are substantially influenced by …

Developments of many renal diseases are substantially influenced by epigenetic
modifications of numerous genes, mainly mediated by DNA methylations, histone …

Epigenetic regulation plays a major role in uremic toxin-induced chronic kidney disease
(CKD) progression. The KLOTHO protein is a key modulator of homeostasis in renal …

Renal fibrosis is a common pathological feature of chronic kidney diseases (CKD) and its
development and progression are significantly affected by epigenetic modifications such as …

Hypoxia is a key pathogenetic characteristic of chronic kidney disease (CKD). Klotho has
renoprotective effect and its expression is commonly suppressed in CKD patients. We …

To explore whether epigallocatechin-3-gallate (EGCG) improves renal damage in diabetic
db/db mice and high-glucose-(HG-) induced injury in HK-2 cells by regulating the level of …

Klotho was discovered as an antiaging gene, and α-Klotho (Klotho) is expressed in multiple
tissues with a broad set of biologic functions. Membrane-bound Klotho binds fibroblast …