Background—The natural history of heterogeneous atherosclerotic plaques and the role of
local hemodynamic factors throughout their development are unknown. We performed a …

The heterogeneity of plaque formation, the vascular remodelling response to plaque
formation, and the consequent phenotype of plaque instability attest to the extraordinarily …

Background—Low endothelial shear stress (ESS) promotes the development of
atherosclerosis; however, its role in the progression of atherosclerotic plaques and evolution …

Aim We performed serial intracoronary studies of patients with stable coronary artery
disease (CAD) to investigate the relationships among baseline endothelial shear stress …

Low ESS determines the severity of vascular inflammation, the status of the extracellular
matrix, and the nature of wall remodeling, all of which synergistically promote the transition …

Although the entire coronary tree is exposed to the atherogenic effect of the systemic risk
factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory …

Objective—The mechanisms promoting the focal formation of rupture-prone coronary
plaques in vivo remain incompletely understood. This study tested the hypothesis that …

Background Experimental studies suggest that low wall shear stress (WSS) promotes
plaque development and high WSS is associated with plaque destabilization. We …

The predilection sites of atherosclerotic plaques implicate rheologic factors like shear stress
underlying the genesis of atherosclerosis. Presently no technique is available that enables …

Background—Native atherosclerosis and in-stent restenosis are focal and evolve
independently. The endothelium controls local arterial responses by transduction of shear …