TR Wilson, PG Johnston… - Current cancer drug …, 2009 - ingentaconnect.com
Resistance to chemotherapy is a major obstacle in the treatment of cancer. Despite the advent of new chemotherapies and molecular-targeted therapies, approximately 90% of …
M Tolomeo, D Simoni - Current Medicinal Chemistry-Anti …, 2002 - ingentaconnect.com
Modulation of multidrug resistance (MDR) has been extensively studied in vitro and in vivo. However, several clinical trials have failed to show any important benefits in terms of …
Drug resistance, to date, has primarily been attributed to increased drug export or detoxification mechanisms. Despite correlations between drug export and drug resistance, it …
Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant …
Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including …
P Gimenez-Bonafe, A Tortosa… - Current cancer drug …, 2009 - ingentaconnect.com
Drug resistance remains a major clinical challenge for cancer treatment. One mechanism by which tumor cells develop resistance to cytotoxic agents and radiation is related to …
H Zahreddine, KLB Borden - Frontiers in pharmacology, 2013 - frontiersin.org
Cancer drug resistance continues to be a major impediment in medical oncology. Clinically, resistance can arise prior to or as a result of cancer therapy. In this review, we discuss …
T Mashima, T Tsuruo - Drug resistance updates, 2005 - Elsevier
Over the past 10 years evidence has been accumulating that antitumour agents induce apoptosis in cancer cells and that abnormalities in apoptosis signaling pathways often occur …
H Lage - Cellular and molecular life sciences, 2008 - Springer
Although various mechanisms involved in anticancer multidrug resistance (MDR) can be identified, it remains a major problem in oncology. Beyond that, the introduction of new …