TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer
MD Park, I Reyes-Torres, J LeBerichel, P Hamon… - Nature …, 2023 - nature.com
Natural killer (NK) cells are commonly reduced in human tumors, enabling many to evade
surveillance. Here, we sought to identify cues that alter NK cell activity in tumors. We found …
surveillance. Here, we sought to identify cues that alter NK cell activity in tumors. We found …
Exploring the impact of TREM2 in tumor-associated macrophages
Simple Summary TREM2+ macrophages were recently reported to be highly enriched and
associated with immunosuppression in various cancer types. Hence, TREM2 targeting …
associated with immunosuppression in various cancer types. Hence, TREM2 targeting …
Immunosuppressive TREM2 (+) macrophages are associated with undesirable prognosis and responses to anti-PD-1 immunotherapy in non-small cell lung cancer
H Zhang, Z Liu, H Wen, Y Guo, F Xu, Q Zhu… - Cancer Immunology …, 2022 - Springer
Background Immune checkpoint blockade (ICB) has been improving patient outcomes of
non-small cell lung cancer (NSCLC), but its effectiveness is highly subjective to individual …
non-small cell lung cancer (NSCLC), but its effectiveness is highly subjective to individual …
Integrated Analysis Highlights the Immunosuppressive Role of TREM2+ Macrophages in Hepatocellular Carcinoma
L Zhou, M Wang, H Guo, J Hou, Y Zhang, M Li… - Frontiers in …, 2022 - frontiersin.org
Recently, attention has been focused on the central role of TREM2 in diverse pathologies.
However, the role of TREM2 signaling in the tumor microenvironment of hepatocellular …
However, the role of TREM2 signaling in the tumor microenvironment of hepatocellular …
TREM1 activation of myeloid cells promotes antitumor immunity
V Juric, E Mayes, M Binnewies, T Lee… - Science Translational …, 2023 - science.org
Myeloid cells in the tumor microenvironment (TME) can exist in immunosuppressive and
immunostimulatory states that impede or promote antitumor immunity, respectively. Blocking …
immunostimulatory states that impede or promote antitumor immunity, respectively. Blocking …
TREM2 marks tumor-associated macrophages
K Nakamura, MJ Smyth - Signal Transduction and Targeted Therapy, 2020 - nature.com
Immunosuppressive myeloid cells are recognized as a key barrier for cancer
immunotherapy. Using an integrated technology for single-cell RNA-sequencing and …
immunotherapy. Using an integrated technology for single-cell RNA-sequencing and …
Targeting TREM2 on tumor-associated macrophages enhances immunotherapy
M Binnewies, JL Pollack, J Rudolph, S Dash… - Cell reports, 2021 - cell.com
Converting checkpoint inhibitor (CPI)-resistant individuals to being responsive requires
identifying suppressive mechanisms. We identify TREM2+ tumor-associated macrophages …
identifying suppressive mechanisms. We identify TREM2+ tumor-associated macrophages …
Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti–PD-1 resistance
The triggering receptor expressed on myeloid cell 1 (TREM1) plays a critical role in
development of chronic inflammatory disorders and the inflamed tumor microenvironment …
development of chronic inflammatory disorders and the inflamed tumor microenvironment …
Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary
Cancer mortality primarily stems from metastatic recurrence, emphasizing the urgent need
for developing effective metastasis-targeted immunotherapies. To better understand the …
for developing effective metastasis-targeted immunotherapies. To better understand the …
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of
cancer progression. Established tumors contain phenotypically distinct, tumor-specific …
cancer progression. Established tumors contain phenotypically distinct, tumor-specific …