Trettenbrein has argued that the concept of the synapse as the locus of memory is outdated
and has made six critiques of this concept. In this article, we examine these six critiques and …

Synaptic plasticity is widely considered to be the neurobiological basis of learning and
memory by neuroscientists and researchers in adjacent fields, though diverging opinions …

During the past two centuries, the study of learning and memory has been central to three
disciplines: first philosophy, then psychology, and now biology. Biological inquiry began in …

It has been 70 years since Donald Hebb published his formalized theory of synaptic
adaptation during learning. Hebb's seminal work foreshadowed some of the great …

Karl Lashley began the search for the engram nearly seventy years ago. In the time since,
much has been learned but divisions remain. In the contemporary neurobiology of learning …

BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

Memorizing new facts and events means that entering information produces specific
physical changes within the brain. According to the commonly accepted view, traces of …

Memory refers to knowledge that is stored in the brain, and to the processes of acquiring,
consolidating and retrieving such knowledge (see Chapter 1). Memory is, arguably, the most …

The modification of synaptic strength produced by long-term potentiation (LTP) is widely
thought to underlie memory storage. Indeed, given that hippocampal pyramidal neurons …

It is generally accepted that complex memories are stored in distributed representations
throughout the brain, however the mechanisms underlying these representations are not …