The COVID‐19 pandemic caused by the SARS‐CoV‐2 has mobilized scientific attention in
search of a treatment. The cysteine‐proteases, main protease (Mpro) and papain‐like …

The main protease (M pro) of the novel coronavirus SARS-CoV-2 is a key target for
developing antiviral drugs. Ebselen (EbSe) is a selenium-containing compound that has …

Featured Application Density functional theory and docking studies applied to the
understanding of the chemical binding of the Mpro-inhibitor ebselen to the enzyme catalytic …

Abstract Coronavirus disease 2019 (COVID-19), an infectious disease caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a global …

The SARS-CoV-2 pandemic has prompted global efforts to develop therapeutics. The main
protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral …

The main protease (Mpro or 3CLpro) of SARS-CoV-2 virus is a cysteine enzyme critical for
viral replication and transcription, thus indicating a potential target for antiviral therapy. A …

The inhibition mechanism of the main protease (Mpro) of SARS-CoV-2 by ebselen (EBS)
and its analog with a hydroxyl group at position 2 of the benzisoselenazol-3 (2H)-one ring …

SARS-CoV-2 main protease (Mpro/3CLpro) is a crucial target for therapeutics, which is
responsible for viral polyprotein cleavage and plays a vital role in virus replication and …

Abstract Ebselen (SPI-1005) is an active selenoorganic compound that can be found
potential inhibitory activity against different types of viral infections such as zika virus …

An efficient treatment against a COVID-19 disease, caused by the novel coronavirus SARS-
CoV-2 (CoV2), remains a challenge. The papain-like protease (PLpro) from the human …