The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …

Macrophages are central to host defense against microbes, but intracellular pathogens have
evolved to evade their antimicrobial functions. Mycobacterium tuberculosis (MTB) has …

One quarter of the world's population is infected with Mycobacterium tuberculosis (Mtb), the
causative agent of tuberculosis (TB). Although most infected individuals successfully control …

A key to the pathogenic success of Mycobacterium tuberculosis (Mtb), the causative agent of
tuberculosis, is the capacity to survive within host macrophages. Although several factors …

Host genetics plays an important role in determining the outcome of Mycobacterium
tuberculosis infection. We previously found that Collaborative Cross (CC) mouse strains …

Over the past 200 years, tuberculosis (TB) has caused more deaths than any other infectious
disease, likely infecting more people than it has at any other time in human history …

M ycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system
before the initiation of an adaptive immune response. This innate protection requires a …

Although mouse infection models have been extensively used to study the host response to
Mycobacterium tuberculosis, their validity in revealing determinants of human tuberculosis …

Genetic factors play a key role in host response, disease severity, and ultimate outcome of
infection with Mycobacterium tuberculosis in humans. In the mouse, the DBA/2J strain is very …

Effective tuberculosis treatment requires at least 6 months of combination therapy.
Alterations in the physiological state of the bacterium during infection are thought to reduce …