Enhancers are genomic elements that regulate gene expression through a variety of
mechanisms. In neuronal systems, enhancer-promoter interactions regulate cell-and tissue …

Transcriptional enhancers are regulatory DNA elements that underlie the specificity and
dynamic patterns of gene expression. Over the past decade, large-scale functional …

Enhancers are non-coding DNA elements that function in cis to regulate transcription from
nearby genes. Through direct interactions with gene promoters, enhancers give rise to …

Sprinkled throughout the genome are a million regulatory sequences called transcriptional
enhancers that activate gene promoters in the right cells, at the right time. Enhancers endow …

Over the last decade, the noncoding part of the genome has been shown to harbour
thousands of cis-regulatory elements, such as enhancers, that activate well-defined gene …

Neuronal activity-regulated gene expression plays a crucial role in sculpting neural circuits
that underpin adaptive brain function. Transcriptional enhancers are now recognized as key …

The neocortex is the region that most distinguishes human brain from other mammals and
primates [Annu Rev Genet. 2021 Nov; 55 (1): 555–81]. Studying the development of human …

Each language has standard books describing that language's grammatical rules. Biologists
have searched for similar, albeit more complex, principles relating enhancer sequence to …

Successful development depends on the precise tissue‐specific regulation of genes by
enhancers, genetic elements that act as switches to control when and where genes are …

Although often located at a distance from their target gene promoters, enhancers are the
primary genomic determinants of temporal and spatial transcriptional specificity in …