The lung is a unique organ in that it is exposed to physical forces derived from breathing,
blood flow, and surface tension throughout life. Over the past decade, significant progress …

The lung is a dynamic organ that is subjected to mechanical forces throughout development
and adult life. This review article addresses the types of mechanical forces in the lung and …

Epithelial cells of the lung are located at the interface between the environment and the
organism and serve many important functions including barrier protection, fluid balance …

Mechanical stress plays a critical role among development, functional maturation, and
pathogenesis of pulmonary tissues, especially for the alveolar epithelial cells and vascular …

Lung function is inextricably linked to mechanics. On short timescales every breath
generates dynamic cycles of cell and matrix stretch, along with convection of fluids in the …

▪ Abstract Gas exchange, the primary function of the lung, can come about only with the
application of physical forces on the macroscale and their transmission to the scale of small …

Mechanical forces affect both the function and phenotype of cells in the lung. In this
symposium, recent studies were presented that examined several aspects of biomechanics …

▪ Abstract Airways are embedded in the mechanically dynamic environment of the lung. In
utero, this mechanical environment is defined largely by fluid secretion into the developing …

In many species, partial resection of the lung leads to rapid compensatory growth of the
remaining tissue to restore normal lung mass and function. The response to partial …

Mechanical ventilation may induce or aggravate lung injury, a phenomenon known as
ventilator induced lung injury (VILI). On a macroscopic level, the effects of mechanical stress …