Background The HIV pandemic is characterized by extensive genetic variability, which has
challenged the development of HIV drugs and vaccines. Although HIV genomes have been …

The global distribution of HIV-1 subtypes and recombinants is extremely complex and
dynamic. The increasing diversity has profound implications for many aspects of the …

Background Global genetic diversity of HIV-1 is a major challenge to the development of HIV
vaccines. We aimed to estimate the regional and global distribution of HIV-1 subtypes and …

The global diversity of HIV forms a major challenge to the development of an HIV vaccine, as
well as diagnostic, drug resistance, and viral load assays, which are essential to reaching …

Background Genetic variability is a major feature of human immunodeficiency virus type 1
(HIV-1) and is considered the key factor frustrating efforts to halt the HIV epidemic. A proper …

Background HIV poses significant challenges for vaccine development due to its high
genetic mutation and recombination rates. Understanding the distribution of HIV subtypes …

As the epidemiological epicenter of the human immunodeficiency virus (HIV) pandemic, the
Democratic Republic of the Congo (DRC) is a reservoir of circulating HIV strains exhibiting …

HIV-1 sequence diversity is affected by selection pressures arising from host genomic
factors. Using paired human and viral data from 1071 individuals, we ran> 3000 genome …

The devastating consequences of AIDS pandemic will probably only be controlled when a
vaccine is developed that is safe, effective, affordable, and simple enough to permit …

The human immunodeficiency virus type 1 (HIV-1) originated in non-human primates in
West-central Africa and continues to be a major global public health issue, having claimed …