Hydrogels are attractive materials for tissue engineering, but efforts to date have shown
limited ability to produce the microstructural features necessary to promote cellular self …

The heart possesses a complex three-dimensional (3D) laminar myofiber organization;
however, because engineering physiologically relevant 3D tissues remains a technical …

This protocol describes a cell/hydrogel molding method for precise and reproducible
biomimetic fabrication of three-dimensional (3D) muscle tissue architectures in vitro. Using a …

Organized cellular alignment is critical to controlling tissue microarchitecture and biological
function. Although a multitude of techniques have been described to control cellular …

Here we report the 3D bioprinting of a simplified model of the heart, similar to that observed
in embryonic development, where the heart is a linear tube that pumps blood and nutrients …

Recent advances in embedded three-dimensional (3D) bioprinting have expanded the
design space for fabricating geometrically complex tissue scaffolds using hydrogels with …

To promote the transition of cell cultures from 2D to 3D, hydrogels are needed to biomimic
the extracellular matrix (ECM). One potential material for this purpose is gellan gum (GG), a …

Biomedical research has relied on animal studies and conventional cell cultures for
decades. Recently, microphysiological systems (MPS), also known as organs-on-chips, that …

Collagen is the primary component of the extracellular matrix in the human body. It has
proved challenging to fabricate collagen scaffolds capable of replicating the structure and …

Cellular models are needed to study human development and disease in vitro, and to
screen drugs for toxicity and efficacy. Current approaches are limited in the engineering of …