The etiology and effect of age-related immune dysfunction in cancer is not completely
understood. Here we show that limited priming of CD8+ T cells in the aged tumor …

Nurture over nature for old antitumor T cells | Nature Immunology Skip to main content Thank you
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Defective host defenses later in life are associated with changes in immune system activity.
The means to correct immune defects to ensure immunity in the elderly are undefined. In this …

Senescence induces key phenotypic changes that can modulate immune responses. Four
recent publications in Cancer Discovery, Nature, and Nature Cancer highlight how …

Aging is associated with a decline in immune function, particularly within the T cell
compartment. Because CD8+ T cells are critical mediators of protective immunity against …

Defective host defenses later in life are associated with changes in immune cell activities,
suggesting that age-specific considerations are needed in immunotherapy approaches. In …

The immune system undergoes a progressive functional remodeling with age.
Understanding how age bias shapes antitumor immunity is essential in designing effective …

Decline in immune function and inflammation concomitantly develop with ageing. Here we
focus on the impact of this inflammatory environment on T cells, and demonstrate that in …

The functional state of the preexisting T cells in the tumor microenvironment is a key
determinant for effective antitumor immunity and immunotherapy. Increasing evidence …

Most cancers emerge in elderly and immune-comprised hosts implying an important role for
cancer immune surveillance. Here, we focus on the role of tissue-associated innate immune …