Antibody drug conjugates in gastrointestinal cancer: From lab to clinical development

D Singh, D Dheer, A Samykutty, R Shankar - Journal of Controlled Release, 2021 - Elsevier
The antibody-drug conjugates (ADCs) are one the fastest growing biotherapeutics in
oncology and are still in their infancy in gastrointestinal (GI) cancer for clinical applications to …

[HTML][HTML] Antibody-drug conjugates: beyond current approvals and potential future strategies

S Menon, S Parakh, AM Scott… - Exploration of targeted anti …, 2022 - ncbi.nlm.nih.gov
The recent approvals for antibody-drug conjugates (ADCs) in multiple malignancies in
recent years have fuelled the ongoing development of this class of drugs. These novel …

[HTML][HTML] Antibody-drug conjugates: the clinical development in gastric cancer

Y Zhu, M Zhou, W Kong, C Li - Frontiers in Oncology, 2023 - frontiersin.org
Gastric cancer (GC) is a prevalent malignant tumor of the digestive system worldwide,
ranking among the top five in terms of incidence and mortality. However, the clinical efficacy …

Antibody drug conjugates in the clinic

E Udofa, D Sankholkar, S Mitragotri… - Bioengineering & …, 2024 - Wiley Online Library
Abstract Antibody‐drug conjugates (ADCs), chemotherapeutic agents conjugated to an
antibody to enhance their targeted delivery to tumors, represent a significant advancement …

[HTML][HTML] Antibody–Drug Conjugates: The Dynamic Evolution from Conventional to Next-Generation Constructs

V Metrangolo, LH Engelholm - Cancers, 2024 - mdpi.com
Simple Summary Since the first antibody–drug conjugate (ADC) was approved in 2000, the
landscape of these targeted drugs has evolved over the years, profoundly changing the …

Unlocking the potential of antibody–drug conjugates for cancer therapy

JZ Drago, S Modi, S Chandarlapaty - Nature Reviews Clinical …, 2021 - nature.com
Nine different antibody–drug conjugates (ADCs) are currently approved as cancer
treatments, with dozens more in preclinical and clinical development. The primary goal of …

Development of antibody‐drug conjugates in cancer: Overview and prospects

DY Ruan, HX Wu, Q Meng, RH Xu - Cancer Communications, 2024 - Wiley Online Library
In recent years, remarkable breakthroughs have been reported on antibody‐drug
conjugates (ADCs), with 15 ADCs successfully entering the market over the past decade …

[HTML][HTML] Antibody–drug conjugates: Ushering in a new era of cancer therapy

J Hurwitz, LR Haggstrom, E Lim - Pharmaceutics, 2023 - mdpi.com
Antibody–drug conjugates (ADCs) have provided new therapeutic options and significant
promise for patients with cancer, particularly where existing treatments are limited …

Targeting cancer with antibody-drug conjugates: Promises and challenges

AQ Dean, S Luo, JD Twomey, B Zhang - MAbs, 2021 - Taylor & Francis
Antibody-drug conjugates (ADCs) are a rapidly expanding class of biotherapeutics that
utilize antibodies to selectively deliver cytotoxic drugs to the tumor site. As of May 2021, the …

Biomarkers for Antibody–Drug Conjugates in Solid Tumors

J Katrini, L Boldrini, C Santoro, C Valenza… - Molecular Cancer …, 2024 - AACR
The clinical development and then the progressive entry in clinical practice of antibody–drug
conjugates (ADC) have marked a transformative advancement in the overall cancer …