[HTML][HTML] AlphaFold and implications for intrinsically disordered proteins
Accurate predictions of the three-dimensional structures of proteins from their amino acid
sequences have come of age. AlphaFold, a deep learning-based approach to protein …
sequences have come of age. AlphaFold, a deep learning-based approach to protein …
Uncovering non-random binary patterns within sequences of intrinsically disordered proteins
Sequence-ensemble relationships of intrinsically disordered proteins (IDPs) are governed
by binary patterns such as the linear clustering or mixing of specific residues or residue …
by binary patterns such as the linear clustering or mixing of specific residues or residue …
Intrinsic protein disorder and conditional folding in AlphaFoldDB
Intrinsically disordered regions (IDRs) defying the traditional protein structure–function
paradigm have been difficult to analyze. The availability of accurate structure predictions on …
paradigm have been difficult to analyze. The availability of accurate structure predictions on …
Towards decoding the sequence-based grammar governing the functions of intrinsically disordered protein regions
A substantial portion of the proteome consists of intrinsically disordered regions (IDRs) that
do not fold into well-defined 3D structures yet perform numerous biological functions and are …
do not fold into well-defined 3D structures yet perform numerous biological functions and are …
AlphaFold2: a role for disordered protein/region prediction?
The development of AlphaFold2 marked a paradigm-shift in the structural biology
community. Herein, we assess the ability of AlphaFold2 to predict disordered regions …
community. Herein, we assess the ability of AlphaFold2 to predict disordered regions …
Introduction to intrinsically disordered proteins and regions
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are
fascinating dynamic conformational ensembles that are observed under physiological …
fascinating dynamic conformational ensembles that are observed under physiological …
Highly accurate protein structure prediction for the human proteome
Protein structures can provide invaluable information, both for reasoning about biological
processes and for enabling interventions such as structure-based drug development or …
processes and for enabling interventions such as structure-based drug development or …
Intrinsically disordered proteins and intrinsically disordered protein regions
CJ Oldfield, AK Dunker - Annual review of biochemistry, 2014 - annualreviews.org
Intrinsically disordered proteins (IDPs) and IDP regions fail to form a stable structure, yet
they exhibit biological activities. Their mobile flexibility and structural instability are encoded …
they exhibit biological activities. Their mobile flexibility and structural instability are encoded …
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2
The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …
proteins. For the majority of human proteins that contain intrinsically disordered regions …
Accurate prediction of protein disordered regions by mining protein structure data
Intrinsically disordered regions in proteins are relatively frequent and important for our
understanding of molecular recognition and assembly, and protein structure and function …
understanding of molecular recognition and assembly, and protein structure and function …