Transcription factors (TFs) can define distinct cellular identities despite nearly identical DNA-
binding specificities. One mechanism for achieving regulatory specificity is DNA-guided TF …

The extensive array of basic helix-loop-helix (bHLH) transcription factors and their
combinations as dimers underpin the diversity of molecular function required for cell type …

Craniofacial morphogenesis is driven by spatial–temporal terrains of gene expression,
which give rise to stereotypical pattern formation. Transcription factors are key cellular …

The rapid increase in gene-centric biological knowledge coupled with analytic approaches
for genomewide data integration provides an opportunity to develop systems-level …

Twist1 and Twist2 are highly conserved members of the Twist subfamily of bHLH proteins
responsible for the transcriptional regulation of the developmental programs in …

During development, transcription factors select distinct gene programs, providing the
necessary regulatory complexity for temporal and tissue-specific gene expression. How …

Transcription factors belonging to the basic helix–loop–helix (bHLH) family have been
shown to control differentiation of a variety of cell types. Tissue-specific bHLH proteins …

The mammalian HoxD cluster lies between two topologically associating domains (TADs)
matching distinct enhancer-rich regulatory landscapes. During limb development, the …

Basic helix–loop–helix (bHLH) transcription factors recognize the canonical E-box
(CANNTG) to regulate gene transcription; however, given the prevalence of E-boxes in a …

The head represents the most complex part of the body and a distinctive feature of the
vertebrate body plan. This intricate structure is assembled during embryonic development in …